Curative efficacy of tripterygium combined with triamcinolone acetonide in the treatment of oral lichen planus
10.3760/cma.j.issn.1008-6706.2018.12.014
- VernacularTitle:雷公藤多苷片联合曲安奈德治疗糜烂型口腔扁平苔藓近期疗效观察
- Author:
Jian DING
1
Author Information
1. 义乌市中心医院口腔科
- Keywords:
Mouth diseases;
Mouth mucosa;
Comparative effectiveness research;
Tipterygium;
Oral lichen planus
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(12):1549-1552
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the curative efficacy of tripterygium combined with triamcinolone acetonide in the treatment of oral lichen planus .Methods 124 patients with erosive oral lichen planus who were treated in Department of Stomatology of Yiwu Central Hospital from September 2015 to March 2017 were selected as the research subjects,and they were randomly divided into two groups according to the digital table ,with 62 cases in eash group . The control group was treated with triamcinolone acetonide ,while the observation group was treated with triamcinolone acetonide combined with tipterygium .Two groups were treated for 4 weeks.The clinical efficacy and adverse reactions were observed in the two groups after treatment ,and the symptoms and changes of blood rheology were observed before and after treatment.Results After treatment,the total effective rate of observation group was statistically higher than that of the control group (90.3％ vs.75.8％,χ2 =4.643,P=0.031).Compared with before treatment ,the signs (t=14.046,P=0.000;t=34.585,P=0.000),pain score (t=31.165,P=0.000;t=49.270,P=0.000) of the two groups were significantly decreased , and the high shear whole blood viscosity , low shear whole blood viscosity , plasma viscosity and erythrocyte sedimentation rate were decreased .After treatment , the above indicators in the observation group were significantly lower than those in the control group (all P<0.05).There was no statistically significant difference between the two groups in incidence rate of adverse reactions ( P >0 .05 ) . Conclusion Tripterygium combined with triamcinolone acetonide in the treatment of oral lichen planus can effectively alleviate the patients'clinical symptoms and blood rheology , significantly improve the clinical curative effect,and has good security .
