Clinical observation of lobaplatin combined with IL -2 thoracic perfusion in the treatment of malignant pleural effusion
10.3760/cma.j.issn.1008-6706.2018.12.003
- VernacularTitle:洛铂联合白细胞介素2胸腔灌注治疗恶性胸腔积液的临床观察
- Author:
Xianfeng GAO
1
;
Yongsheng JIA
Author Information
1. 大同煤矿集团有限责任公司肿瘤医院肿瘤内科
- Keywords:
Pleural effusion;
malignant;
Lobaplatin;
Interleukin -2;
Chemotherapy;
cancer;
regional perfusion;
Quality of life;
Toxic actions;
Comparative effectiveness research
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(12):1506-1510
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect of lobaplatin combined with IL -2 in the treatment of malignant pleural effusion .Methods 42 patients with malignant pleural effusion in Datong Coal Group Co Cancer Hospital form 2014 to 2016 were enrolled as observation group,and treated with lobaplatin combined with IL -2. Another 45 patients with malignant pleural effusion in the same period were selected as control group ,and treated with lobaplatin.The efficacy and toxicity between the two groups were compared .The VEGF,CEA and TSGF were recorded in the two groups .The quality of life was evaluated by QLQ-C30 .Results The CR and PR rates in the observation group were 35.7％and 45.2％,respectively,which in the control group were 15.6％,22.2％,respectively,the differ-ences between the two groups were statistically significant (χ2 =4.672,5.178,all P<0.05).Both two groups showed different degrees of adverse reactions in treatment period,but there was no statistically significant difference in the incidence rate(P>0.05).The levels of VEGF,CEA and TSGF in the observation group were (194.6 ±25.4)ng/L, (42.4 ±9) ng/L and (81.3 ±10.3)U/mL,respectively,which were significantly lower than those in the control group[(195.0 ±24.1)ng/L,(43.1 ±9.5)ng/L,(80.9 ±9.4)U/mL](t =-0.075,-0.340,0.189,all P<0.05 ) .The improvement of dyspnea symptoms ,mood and overall health status in the observation group was better than those in the control group (t =23.326,-2.275,10.757,all P <0.05).Conclusion Lobaplatin combined with IL-2 pleural perfusion has significantly curative effect ,it can improve the quality of life and without increased toxicity in the treatment of malignant pleural effusion .
