Clinical effect of naloxone in the treatment of patients with acute cerebral infarction

VernacularTitle:纳洛酮辅助治疗急性脑梗死的临床疗效观察
Author: Zhijun ZHENG ¹
Author Information

1. 横店文荣医院神经内科
Keywords: Naloxone; Brain infarction; Treatment outcome
From: Chinese Journal of Primary Medicine and Pharmacy 2018;25(10):1290-1293
CountryChina
Language:Chinese
Abstract: Objective To analyze the clinical effect of naloxone in the treatment of patients with acute cerebral infarction ( ACI) .Methods 86 patients with ACI were selected as study objects ,and they were divided into control group and observation group ,with 43 cases in each group .The control group was given conventional treatment , the observation group received conventional treatment combined with naloxone .The treatment effect was compared between the two groups .Results The total effective rate of the observation group was 86.05%,which was higher than 67.44%of the control group(χ2=4.169,P<0.05).After treatment,the NDS score,plasma nitric oxide(NO) and endothelin(ET) in the observation group were (11.55 ±3.89)points,(54.68 ±8.12)μmol/L,(53.98 ±8.44)ng/L, respectively,which in the control group were (17.68 ±3.84)points,(40.75 ±8.23)μmol/L,(68.02 ±8.47)ng/L, respectively,the differences were statistically significant (t =7.354,7.900,7.699,all P <0.05).Conclusion Application of naloxone on the basis of routine treatment in the treatment of ACI can obviously improve the symptoms of hypoxia and therapeutic effect .