Clinical effect of Huayi decoction in the treatment of recurrent endometriosis
10.3760/cma.j.issn.1008-6706.2018.08.016
- VernacularTitle:化异汤治疗复发子宫内膜异位症的疗效观察
- Author:
Xiuhong ZONG
1
;
Cuilan GONG
Author Information
1. 青岛市黄岛区中医医院妇科
- Keywords:
Endometriosis;
Recurrence;
Drugs;
chinese herbal;
Huayi Tan
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(8):1010-1013
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Huayi decoction in the treatment of recurrent endometriosis ,and its influence on Th1/Th2 balance.Methods 92 patients with recurrent endometriosis were selected as the research subjects.According to the digital table method ,the patients were randomly divided into the observation group and the control group,46 cases in each group.The control group was given mifepristone ,every time 12.5mg,1 time/day, continuously treated for 3 months.The observation group was treated with Huayi decoction for 3 months.The serum carbohydrate antigen 125(CA125),interferon gamma(IFN-γ),interleukin 4(IL-4) were measured before and after treatment.Results After treatment,the effective rate of the control group was 78.3％,which was significantly lower than 91.3％ of the observation group (χ2 =5.16,P<0.05).Before and after treatment,the serum CA125 levels of the control group were (103.62 ±27.45) IU/mL,(55.21 ±19.23) IU/mL,respectively.Before and after treatment,the serum CA125 levels of the observation group were (106.85 ±22.74)IU/mL,(31.47 ±12.94)IU/mL, respectively.After treatment,the serum CA125 levels were significantly lower in the two groups (t=10.963,14.206, all P<0.01),and the serum CA125 level in the observation group was significantly lower than that in the control group (t=5.038,P <0.05).The IL -4,IFN -γ,IL -4/IFN -γof the control group before treatment were (22.61 ±6.72) pg/mL,(51.77 ±8.09) pg/mL and (0.41 ±0.11),respectively,which after treatment were (15.16 ±5.04)pg/mL,(60.39 ±9.14)pg/mL and (0.22 ±0.07),respectively.The IL-4,IFN-γ,IL-4/IFN-γof the observation group before treatment were (23.01 ±6.71) pg/mL,(51.16 ±7.63) pg/mL and (0.42 ± 0.15),respectively,which after treatment were (9.03 ±3.37)pg/mL,(69.91 ±8.24)pg/mL and (0.12 ±0.05), respectively.After treatment,the serum IL-4 levels of the two groups were significantly lower (t=6.0143,8.770,all P<0.01),and the decrease of IL -4 level of the observation group was more significant (t=3.448,P<0.05).After treatment,the serum IFN-γlevels were significantly higher in the two groups (t=2.014,2.998,all P<0.05),and the increase of IFN-γlevel of the observation group was more significant (t=2.106,P<0.05).After treatment,the serum IL-4/IFN-γof the two groups were significantly lower (t=5.182,9.062,all P<0.01),and the IL-4/IFN-γdecreased more significantly in the observation group (t=5.824,P<0.05).Conclusion Huayi decoction can significantly improve the postoperative curative effect and improve the imbalance of Th 1/Th2.
