Effect of aspirin combined with clopidogrel in the treatment of transient ischemic attack and its influence on coagulation function
10.3760/cma.j.issn.1008-6706.2018.07.025
- VernacularTitle:阿司匹林联合氯吡格雷治疗短暂性脑缺血发作的疗效及对凝血功能的影响
- Author:
Bin ZHANG
1
Author Information
1. 聊城市第三人民医院神经内科
- Keywords:
Aspirin;
Clopidogrel;
Ischemic attack,transient;
Fibrinogen;
Prothrombin time;
Activated partial thromboplastin time
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(7):911-914
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of aspirin combined with clopidogrel in the treatment of transient ischemic attack (TIA),and its influence on blood coagulation.Methods Ninety-six patients with TIA were selected and divided into observation group and control group by random number table method,with 48 cases in each group.The control group was treated with aspirin,and the observation group was treated with aspirin and clopidogrel.The treatment effect,coagulation index changes and adverse reactions were compared between the two groups.Results The effective rate of the observation group was 91.67％ (44/48),which was higher than 68.75％ (33/48) of the control group (x2 =7.941,P ＜ 0.05).After treatment,the fibrinogen(FIB) levels in the observation group and the control group were (2.07 ± 0.32) g/L and (2.91 ± 0.31) g/L,respectively,which were significantly lower than before treatment [(3.28 ± 0.41) g/L,(3.26 ± 0.39) g/L] (robservation group =5.546,t l group =4.258,all P ＜ 0.05),and FIB level of the observation group was lower than that of the control group (t =11.481,P ＜ 0.05).After treatment,the prothrombin time(PT) and activated partial thromboplastin time(APTT) in the observation group and the control group were (15.04 ± 1.81) s,(36.98 ± 4.35) s and (12.04 ± 1.68) s,(30.68 ± 4.46) s,respectively,which were significantly longer than before treatment [(9.68 ± 1.59) s,(9.71 ± 1.61) s and (25.21 ± 4.48) s,(25.34 ±4.36) s] (tobservation group =6.994,6.425,tcontrol group =5.658,5.987,all P ＜ 0.05),and PT and APTT of the observation group were longer than those of the control group(t =7.941,6.874,all P ＜ 0.05).The incidence rate of adverse reactions in the observation group was 4.17％ (2/48),which in the control group was 6.25％ (3/48),there was no statistically significant difference between the two groups (x2 =0.694,P ＞ 0.05).Conclusion The curative effect of aspirin combined with clopidogrel is superior to aspirin alone in the treatment of TIA,and it can improve the coagulation function of patients,which has high security.
