Influence of continuous renal replacement therapy combined with hemoperfusion on the pulmonary function and prognosis of patients with severe acute pancreatitis
10.3760/cma.j.issn.1008-6706.2018.07.020
- VernacularTitle:早期连续性肾脏替代治疗联合血液灌流对急性重症胰腺炎患者肺功能及预后的影响
- Author:
Jian MA
1
;
Zhi ZHAO
;
Chang DU
Author Information
1. 北京市昌平区医院急诊科
- Keywords:
Renal replacement therapy;
Hemoperfusion;
Pancreatitis,acute necrotizing;
Respiratory function tests;
Prognosis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(7):890-894
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of continuous renal replacement therapy (CRRT) combined with hemoperfusion(HP) on the pulmonary function and prognosis of patients with severe acute pancreatitis(SAP).Methods 62 patients were chosen as study objects,and they were divided into CRRT group (31 cases) and CRRT + HP group (31 cases) according to the digital table.After treatment,the incidence rate of acute liver injury (ALI) /acute respiratory distress syndrome (ARDS),mortality,PaO2,PaO2 / FiO2,tumor necrosis factor α (TNF-α) and IL-18 levels were compared.Results The incidence rate of ALI/ARDS and mortality in the CRRT + HP group were 22.58％ (7/31) and 6.45 ％ (2/31),respectively,which in the CRRT group were 51.61％ (16/31),25.81％ (8/31),respectively,the differences between the two groups were statistically significant (x2 =5.599,4.292,all P ＜0.05).After treatment,the PaO2 and PaO2/FiO2 of the CRRT + HP group were (85.9 ±7.6)mmHg and (245.8 ±35.6)mmHg,respectively,which were higher than those of the CRRT group [(69.8 ±9.4)mmHg,(198.6 ±31.2)mmHg] (t =5.912,5.314,all P ＜ 0.05).The TNF-α and IL-18 levels of the CRRT + HP group were (11.95 ± 0.67) ng/L and (325.87 ± 84.17)ng/L,respectively,which were lower than those of the CRRT group [(17.32 ± 0.54)ng/L,(441.08 ±72.97)ng/L],and the differences were statistically significant (t =5.174,6.771,all P ＜ 0.05).Conclusion CRRT combined with HP can alleviate pulmonary function and prognosis of patients with SAP.
