Comparison of the effects of different blood purification methods on inflammatory cytokines clearance in patients with maintenance hemodialysis
10.3760/cma.j.issn.1008-6706.2018.07.015
- VernacularTitle:不同血液净化方式对维持性血液透析患者炎性因子清除效果的比较
- Author:
Xiaoqin GAO
1
;
Weimin YU
Author Information
1. 山西医学科学院山西大医院肾内科
- Keywords:
Hemodiafiltration;
C-Reactive protein;
Tumor necrosis factor-alpha;
Interleukins;
Controlled clinical trial
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(7):871-873
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of different ways of blood purification on inflammatory cytokines clearance in patients with maintenance hemodialysis.Methods The clinical data of 50 patients with maintenance hemodialysis were retrospectively analyzed.The low flux dialysis,high flux dialysis were used respectively,and the changes of hypersensitive C-reactive protein (hs-CRP),tumor necrosis factor alpha (TNF-α),interleukin 1 (IL-1),interleukin 6 (IL-6) after dialysis were compared between the two methods.Results After low flux dialysis,the hs-CRP,TNF-α,IL-1,IL-6 levels were (6.58 ± 3.69) mg/L,(1.54 ± 0.42) g/L,(105.46 ±8.20) ng/L,(27.58 ± 6.83) ng/L,respectively,which after high flux dialysis were (2.93 ± 1.85) mg/L,(1.13 ±0.27) g/L,(97.21 ± 7.l4.) ng/L,(20.35 ± 5.76) ng/L,respectively,the differences were statistically significant (t =6.253,5.806,5.365,5.806,all P ＜ 0.05).Conclusion Compared with the low flux dialysis,high flux dialysis is more effective in inflammatory cytokines clearance in patients with maintenance hemodialysis.
