Changes of serum levels of interleukin-13 and squamous cell carcinoma antigen in children with asthma and its clinical significance
10.3760/cma.j.issn.1008-6706.2018.07.001
- VernacularTitle:哮喘患儿血清白细胞介素13、鳞状细胞癌抗原的水平变化及意义
- Author:
Xiyan ZHANG
1
;
Min ZHANG
;
Huijun SONG
Author Information
1. 中国医科大学附属第四医院儿科
- Keywords:
Asthma;
Interleukin-13;
Squamous cell carcinoma antigen;
Child
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(7):817-819
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of serum interleukin-13 (IL-13) and squarnous cell carcinoma antigen (SccAg) levels in pediatric asthma and its clinical significance.Methods 45 children with pediatric asthma were selected as observation group,45 healthy children at the same time were selected as control group.IL-13 and SccAg levels in the two groups were detected by ELISA.The correlation between the serum IL-13,SccAg levels and pediatric asthma was analyzed.Results In the observation group,the IL-13,SccAg levels at the attack stage were (148.96 ± 24.56) ng/L,(3.36 ± 0.69) μg/L,respectively,the IL-13,SccAg levels at the remission stage were (90.65 ± 20.14)ng/L,(2.58 ± 0.34) μg/L,respectively,which in the control group were (76.48 ± 17.54) ng/L,(2.30 ± 0.36) μg/L,respectively,the differences were statistically significant (F =5.36,6.39,all P ＜ 0.05).In the observation group,the IL-13,SccAg levels in the patients with moderate or severe disease were (135.48 ± 21.69)ng/L,(2.86 ± 0.36) μg/L,respectively,the IL-13,SccAg levels in the patients with mild disease were (160.38 ± 22.45) ng/L,(3.30 ±0.41) μg/L,respectively,which in the control group were (76.48 ± 17.54) ng/L,(2.30 ± 0.36) μg/L,respectively,the differences were statistically significant (F =5.78,6.78,all P ＜ 0.05).The serum IL-13 and SccAg levels had significantly positive correlation with pediatric asthma during the attack stage and remission stage (r =0.982,0.965,all P ＜ 0.05).Conclusion The serum IL-13 and SccAg levels have certain association with the incidence of asthma,which play an important role in determining the development and reorientation of asthma.
