Application progress of drug metabolism model in the innovative drug research
10.3760/cma.j.issn.1008-6706.2018.05.033
- VernacularTitle:药物代谢模型在创新药物研究中的应用进展
- Author:
Minglei WANG
1
Author Information
1. 264400,山东省威海市中心医院物流中心科
- Keywords:
Drug research;
Drug metabolism;
Models in vitro;
Models in vivo
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(5):665-669
- CountryChina
- Language:Chinese
-
Abstract:
To review the current status of drug metabolism model .To retrieve,analyze and summarize the relevant literatures of the database.There are many kinds of drug metabolism models and mechanisms .Every model has its own advantages and disadvantages .The researchers should use in vitro experiments based on the purpose of the study and the existing laboratory conditions .If the compounds have good metabolic properties in vitro ,they can be further tested in vivo to make a reasonable and accurate prediction for drug metabolic properties .
