Efficacy and safety of proton pump inhibitor in treatment of stress ulcer
10.3760/cma.j.issn.1008-6706.2018.05.002
- VernacularTitle:质子泵抑制剂治疗应激性溃疡的疗效观察
- Author:
Lin ZHOU
1
Author Information
1. 宁波市医疗中心李惠利东部医院药剂科
- Keywords:
Proton pump inhibitors;
Stress ulcers;
Adverse reactions;
Quality of life
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(5):549-552
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of proton pump inhibitor in the treatment of stress ulcer.Methods 100 patients with stress ulcer were enrolled ,and they were randomly divided into two groups according to the random number table .The patients in the control group were treated with omeprazole .The patients in the observation group were treated with pantoprazole 40mg intravenous infusion,2 times/day,10 days after treatment, modified to rabeprazole 10mg,2 times /day,oral 6 weeks.The clinical symptoms score,ulcer area,the overall treat-ment,adverse reactions,recurrence rate and quality of life were compared between the two groups .Results After treatment,the clinical symptom score and ulcer area of the observation group were (8.87 ±2.55)points,(19.46 ± 6.88)mm,respectively,which were significantly lower than those of the control group [(12.68 ±3.14) points, (34.20 ±9.77)mm].The markedly effective rate and total effective rate of the observation group were 70%,88%, respectively,which were significantly higher than those of the control group (28%,66%).The recurrence rates of 6 months and 12 months of the observation group were 6% and 26%,respectively,which were significantly lower than those of the control group(28%,52%).The total score of quality of life after 12 months of treatment in the observa-tion group was (635.14 ±55.83)points,which was significantly higher than that of the control group [(578.94 ± 52.40)points,t =5.190,P <0.01].The incidence rate of overall adverse reaction had no statistically significant difference between the two groups (P >0.05).Conclusion Proton pump inhibitor is effective in the treatment of stress ulcer with high safety and has reference significance .
