Clinical observation of ( S) -amlodipine benzenesulfonate combined with atorvastatin calcium tablet in the treatment of hypertension with coronary heart disease
10.3760/cma.j.issn.1008-6706.2018.04.006
- VernacularTitle:苯磺酸左旋氨氯地平与阿托伐他汀钙片合用治疗高血压合并冠心病的临床观察
- Author:
Fengjiao DAI
1
Author Information
1. 313306,浙江省安吉县第二人民医院内科
- Keywords:
Hypertension;
Coronary artery disease;
Amlodipine;
Atorvastatin;
Nifedipine
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(4):429-432
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy of (S)-amlodipine benzenesulfonate combined with atorvastatin calcium in the treatment of hypertension with coronary heart disease .Methods 100 cases were selected and randomly divided into two groups:50 cases in the observation group and 50 cases in the control group .The control group was given nifedipine sustained -release tablets combined with atorvastatin calcium tablets .The treatment group was given ( S) -amlodipine benzenesulfonate combined with atorvastatin calcium tablets .The overall efficacy , the level of dyslipidemia before and after treatment and the 6 -minute walk test (6MWT) of the two groups were observed . Results The decrease of blood pressure:the control group was markedly effective in 12 cases, effective in 23 cases, ineffective in 15 cases,the total effective rate was 70％;The observation group was effective in 19 cases,effective in 26 cases,ineffective in 5 cases,the total effective rate was 92％,the difference between the two groups was statistically significant (χ2 =0.95,P<0.05).As to the episodes of angina pectoris ,in the control group,10 cases were markedly effective,26 cases were effective ,9 cases were ineffective ,5 cases were aggravated ,the total effective rate was 70％, which in the observation group were 18 cases,29 cases,2 cases,1 case,the total effective rate was 94％,there was statistically significant difference between the two groups (χ2 =0.12,P<0.05).After treatment,the TC,TG,LDL-C, HDL-C levels in the control group were (5.62 ±1.08)mmol/L,(1.95 ±0.47)mmol/L,(3.24 ±0.71)mmol/L, (1.19 ±0.45)mmol/L,which in the treatment group were (4.38 ±0.92)mmol/L,(1.90 ±0.41)mmol/L,(1.83 ± 0.62)mmol/L,(1.42 ±0.42)mmol/L,there were statistically significant differences between the two groups (t=2.69,2.41,all P<0.05).(4)6MWT in the control group was (362.12 ±34.60)m after treatment,which of the treatment group was (407.35 ±29.15)m,there was statistically significant difference between the two groups (t =11.73,P <0.05).Conclusion ( S) -amlodipine benzenesulfonate combined with atorvastatin calcium in the treatment of hypertension with coronary heart disease can effectively improve the symptoms , lower blood pressure ,improve patients'exercise tolerance and heart function .
