Observation of tacrolimus ointment combined with ornidazole and clarithromycin in the treatment of rosacea with facial hormone dependent dermatitis
10.3760/cma.j.issn.1008-6706.2018.02.014
- VernacularTitle:他克莫司软膏联合奥硝唑、克拉霉素治疗酒渣鼻合并面部激素依赖性皮炎的疗效观察
- Author:
Huifang LI
1
;
Zhenshou LI
Author Information
1. 平顶山市平煤神马医疗集团总医院皮肤科
- Keywords:
Rhinophyma;
Dermatitis;
Tacrolimus;
Drnidazole;
Clarithromycin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(2):186-189
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy and safety of tacrolimus ointment combined with ornidazole and clarithromycin in the treatment of rosacea with facial hormone dependent dermatitis .Methods A total of 80 cases with rosacea complicated with facial hormone dependent dermatitis were selected , and they were randomly divided into observation group and control group according to the digital table ,40 cases in each group .The observation group was treated with 0.1％ tacrolimus ointment besmear outside 2 times a day,a total of eight weeks,and at the same time,ornidazole and clarithromycin was taken orally for 4 weeks.The control group was treated with 0.1％tacrolimus ointment besmear outside 2 times a day for a total of eight weeks .The curative effects of two groups after treatment,and the symptom rebound rates aftre 4 weeks of treatment were compared .Results The total effective rate of the observation group was 92.5％,which of the control group was 67.5％,the difference between the two groups was statistically significant(χ2 =7.68,P<0.05).The symptom scores before treatment between the two groups had no statistically significant difference[(19.93 ±0.76)points vs.(19.89 ±4.07)points,P>0.05].After treatment, the symptom scors between the two groups had statistically significant difference (P<0.05).The bounce rate of the observation group was 7.5％,which of the control group was 31.58％.The difference between the two groups was statistically significant(χ2 =5.97,P<0.05).Conclusion 0.1％tacrolimus ointment combined with ornidazole and clarithromycin in the treatment of rosacea complicated with hormone-dependent facial dermatitis has satisfied curative effect and security ,the comprehensive treatment is better than single treatment .
