The role and research progress of Wnt/β-catenin signal pathway in the pathogenesis of osteoarthritis or Kashin-Beck disease
10.3760/cma.j.issn.2095-4255.2018.11.019
- VernacularTitle:Wnt/β-catenin信号通路在骨关节炎和大骨节病发病中的作用及研究进展
- Author:
Wanying WANG
1
;
Yun CAI
;
Liyan SUN
Author Information
1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心大骨节病防治研究所
- Keywords:
Osteoarthritis;
Kashin-Beck disease;
Wnt signaling pathway;
Beta catenin
- From:
Chinese Journal of Endemiology
2018;37(11):933-936
- CountryChina
- Language:Chinese
-
Abstract:
Osteoarthritis is a chronic,degenerative joint disease characterized by destruction of articular cartilage,osteophyte formation and narrowing of the joint space,which seriously affects the life quality of patients.However,the pathogenesis of osteoarthritis is still not clear.Kashin-Beck disease (KBD) is an endemic,chronic and deformative osteoarthropathy that mainly occurs in children aged 5-15 years old.The etiology and pathogenesis of KBD are still unclear.Wnt/β-catenin signaling pathway is involved in the development of embryonic cartilage and maintaining the stability of adult bones,which is a key pathway regulating the growth,development and differentiation of chondrocytes.Therefore,the authors review the progress of Wnt/β-catenin signaling pathway in the pathogenesis of osteoarthritis or KBD.
