Effects of activation or blockade of 5-HT1A receptors in the medial septum-diagonal band of Broca complex on cognitive functions in hemiparkinsonian rats
10.7652/jdyxb201804009
- VernacularTitle:激活或阻断内侧隔斜角带复合体中5-HT1A受体对帕金森病模型大鼠认知功能的影响
- Author:
Li-Bo LI
1
;
Kun-Ying LI
;
Fang-Yuan GUO
;
Wen-Juan LI
;
Yue XI
;
Hong-Fei QIAO
;
Feng YANG
;
Qiao-Jun ZHANG
Author Information
1. 西安交通大学医学院第二附属医院康复医学科
- Keywords:
Parkinson's disease;
medial septum-diagonal band of Broca complex;
5-HT1Areceptor;
cognitive function;
hippocampal
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2018;39(4):488-493,497
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role and mechanisms of 5-HT1Areceptors in the medial septum-diagonal band of Broca complex (MS-DB) in hemiparkinsonian rats. Methods Combined behavioral and electrophysiological studies were performed to assess the role of MS-DB 5-HT1Areceptors in working memory and hippocampal theta rhythm in rats with 6-hydroxydopamine (6-OHDA)lesions in the medial forebrain bundle (MFB).Results ① MFB lesions in the rats decreased choice accuracy in the T-maze rewarded alternation test. Intra-MS-DB injection of 5-HT1Areceptor agonist 8-OH-DPAT further decreased choice accuracy,while intra-MS-DB injection of 5-HT1Areceptor antagonist WAY-100635 increased choice accuracy in the lesioned rats.② MFB lesions in the rats decreased peak theta rhythm frequency. Intra-MS-DB injection of 8-OH-DPAT suppressed hippocampal theta rhythm and decreased normalized theta power,while intra-MS-DB injection of WAY-100635 induced theta rhythm and increased normalized theta power.Conclusion Blockade of MS-DB 5-HT1Areceptors can recover cognitive dysfunction in Parkinson's disease, which may be attributed to the enhancement of hippocampal theta rhythm.
