Correlation between tumor-associated macrophages and the occurrence and development of Kazakh esophageal squamous cell carcinoma in Xinjiang
- VernacularTitle:肿瘤相关巨噬细胞与新疆哈萨克族食管鳞癌的相关性分析
- Author:
Kai LIU
1
;
Ji-Hong LIU
;
Xian-Li JIANG
;
Xue-Li WANG
;
Ye YUAN
;
Wei-Yuan YUAN
;
Li-Xia WANG
;
Wei-Hua LIANG
;
Feng LI
;
Jian-Ming HU
Author Information
- Keywords: tumor-associated macrophage(TAM); CD68; esophageal squamous cell carcinoma; Kazakh
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2018;39(2):256-260
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the correlation between tumor-associated macrophages(TAMs)and the occurrence and progression of Kazakh esophageal squamous cell carcinoma.Methods We collected 200 cases of esophageal squamous cell carcinoma(ESCC),cancer adjacent normal(CAN)tissues and clinical pathological data of the specimens.CD68 was used as the TAM marker,and immunohistochemistry(IHC)counts were used to detect the distribution of TAMs and quantify the density of TAMs in tumor nest/epithelial and surrounding stroma.At the same time,by combining with clinical pathological data and the patients' prognosis,we analyzed whether the high density of TAMs distribution was associated with the occurrence and development of Kazakh ESCC and the patients' poor prognosis.Results ① The density of TAMs in the tumor nests and stroma was significantly higher than that in CAN tissues(P＜0.05).② The density of TAMs in tumor nest had a significant positive correlation with lymph node metastasis and clinical pathological stage(advanced)in Kazakh ESCC(P＜ 0.05),and this correlation was more evident between the density of TAMs in tumor stroma and lymph node metastasis and clinical pathological stage (advanced)(P＜0.001).③ The survival analysis found that the high density of CD 68-positive TAMs in cancer nest showed a positive correlation with poor prognosis of ESCC(P＜0.05).Conclusion High density of TAMs can promote the occurrence and development of Kazakh ESCC in Xinjiang and can be used as a poor prognostic factor for ESCC in Kazakh population.
