Research progression of MLLT6 in leukemia
10.11904/j.issn.1002-3070.2018.02.009
- VernacularTitle:MLLT6在白血病中的研究进展
- Author:
Yipeng LI
1
;
Xinyu ZHANG
;
Hanning LV
Author Information
1. 哈尔滨医科大学附属肿瘤医院
- Keywords:
MLLT6;
MLL-MLLT6 fusion protein;
Leukemia;
Blood pressure homeostasis
- From:
Practical Oncology Journal
2018;32(2):135-139
- CountryChina
- Language:Chinese
-
Abstract:
MLLT6(Myeloid/Lymphoid or mixed-lineage leukemia(Trithorax homolog,Drosophila);Translocated to,6),also known as AF17(ALL1 fused gene from chromosome 17 protein)and located in chromosome 17 long arm 2 zone 1 band(17q21),was originally isolated as a MLL partner gene in leukemia.It has been reported that MLLT6 has the function of maintaining blood pressure stability.MLLT6 synergistically promotes the development of acute myeloid leukemia(AML)as an oncogene or a gene fusion with mixed lineage leukemia(t(11;17)(q23;q21)).This article provides a comprehensive overview of the research progress of MLLT6 and MLL-MLLT6 fusion protein in leukemia.
