Expression of MITOL in the cerebrospinal fluid of patients with postherpetic neuralgia and its clinical sig-nificance

VernacularTitle:线粒体泛素连接酶在带状疱疹后遗神经痛患者脑脊液中的表达及意义
Author: Tao TU ¹ ; Yu YE ; Shuhua DONG
Author Information

1. 成都医学院第一附属医院麻醉科成都610500
Keywords: postherpetic neuralgia; mitochondrial ubiquitin ligase; cerebrospinal fluid
From: The Journal of Practical Medicine 2018;34(8):1320-1322,1326
CountryChina
Language:Chinese
Abstract: Objective To explore the expression of mitochondrial ubiquitin ligase(MITOL)in the cere-brospinal fluid from patients with postherpetic neuralgia(PHN). Methods A total of 45 patients who were diag-nosed with PHN in our hospital from August 2015 to December 2016 were enrolled in this study,and 38 gender-and age-matched patients with lumbar disc herniation were recruited as IDH group.The MITOL was measured by the ELISA and Western blot methods.The correlation between the expression of MITOL in cerebrospinal fluids and clinical characteristics of patients with PHN was evaluated.Results The expression of MITOL was significantly in-creased in cerebrospinal fluids of patients with PHN compared with IDH,and it was associated with age and the pain intensity(P<0.05).Logistic regression analysis showed age(OR,2.717)and the pain intensity(OR,3.042) were risk factors for PHN. Conclusions The expression of MITOL is significantly increased in the cerebrospinal fluid of PHN,which may be associated with age and pain intensity.