The clinical application of pretreatment lactate dehydrogenase/albumin ratio in predicting the prognosis of nasopharyngeal carcinoma
10.3969/j.issn.1006-5725.2018.08.015
- VernacularTitle:治疗前乳酸脱氢酶/白蛋白比值预测鼻咽癌预后的价值
- Author:
Jun ZHENG
1
;
Xia XU
;
Xiaoyan FU
Author Information
1. 广州军区广州总医院耳鼻喉科 广州510010
- Keywords:
nasopharyngeal carcinoma;
prognosis;
lactate dehydrogenase;
albumin
- From:
The Journal of Practical Medicine
2018;34(8):1285-1288
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between pretreatment serum lactate dehydrogenase (LDH)to albumin ratio(LAR)and the long-term survival of nasopharyngeal carcinoma patients after definite radiotherapy.Methods A total of 956 treatment-naive nasopharyngeal carcinoma patients receiving definite radio-therapy between October 2007 and December 2009 were collected.Univariate and multivariate model were used to analyze the association between pretreatment LAR and overall survival(OS)or distant-metastasis-free survival (DMFS).Results Based on-line cutoff finder,the optimal cut-off value of LAR was determined to be 0.385.Uni-variate analysis reveals that OS and DMFS were all significantly poorer in the high LAR group than that in the low LAR group(P < 0.001). Cox multivariate regression model shows that high LAR(P < 0.001),age ≥ 45 years (P < 0.001)and stage Ⅲ~Ⅳ(P < 0.001)were independent inferior prognostic factors for OS,while high CAR (P < 0.001)and stage Ⅲ~Ⅳ(P = 0.012)were independent inferior prognostic factor for DMFS. Conclusion Pretreatment LAR is an independent prognostic factor in nasopharyngeal carcinoma and could be used in risk strati-fication and guiding adjuvant therapy.
