Effects of dexmedetomidine on early postoperative cognitive function in elderly patients undergoing liver resection
10.3969/j.issn.1006-5725.2018.04.029
- VernacularTitle:右美托咪定对肝癌手术老年患者术后早期认知功能的影响
- Author:
Biao ZHOU
1
;
Yan LOU
;
Yanxia YU
Author Information
1. 郑州大学附属洛阳中心医院麻醉科 河南洛阳471003
- Keywords:
dexmedetomidine;
hepatocarcinoma;
aged;
postoperative cognitive
- From:
The Journal of Practical Medicine
2018;34(4):638-640,648
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of dexmedetomidine on early postoperative cognitive func-tion in elderly patients undergoing liver resection. Method Fifty-four ASAⅡ~Ⅲelderly patients scheduled for liver resection were divided into 3 groups(18 in each group):the control group(group C),group D1 and group D2. The levels of serum 8-iso-PGF2α,IL-6,TNF-α and S100β protein were measured,and Da-jvO2,CjvO2and CERO2were calculated at the time before operation and at the end of operation,respectively.Incidence of postoper-ative cognitive dysfunction(POCD)were recorded within seven days after operation. Results Compared with the time before operation,levels of serum 8-iso-PGF2α,IL-6,TNF-α,S100β protein and Da-jvO2,CERO2of patients in 3 groups significantly increased at the end of operation(P < 0.05,respectively). The levels of serum 8-iso-PGF2α,IL-6,TNF-α,S100β protein and Da-jvO2,CERO2of patients decreased in group D1 and D2 than those in group C at the end of operation(P<0.05).Incidence of POCD in group D1 and D2 was lower than that of group C (P<0.05).Conclusion Dexmedetomidine can decrease the incidence of POCD for the elderly patients undergo-ing liver resection,the potential mechanism is that dexmedetomidine can reduce oxidative stress response,inhibit inflammatory response in patients and improve the cerebral oxygen metabolism during the operation.
