Inflammatory fibroid polyp: a clinicopathologic and immunohistochemical analysis of 28 cases
10.3969/j.issn.1006-5725.2018.02.033
- VernacularTitle:胃肠道炎性纤维性息肉28例临床病理学分析
- Author:
Zha-Orong NIU
1
;
Daoming LI
Author Information
1. 郑州大学第一附属医院 郑州450000
- Keywords:
gastrointestinal tract;
inflammatory fibroid polyp;
immunohistochemistry;
diagnosis;
differential diagnosis
- From:
The Journal of Practical Medicine
2018;34(2):289-292
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical and pathologic characteristics of inflammatory fibroid polyp (IFP)in gastrointestinal tract,and discuss the diagnosis,differential diagnosis and treatment. Methods The clini-cal and pathologic findings of 28 IFP patients were retrospectively analyzed. Results IFP occurred in 8 males and 20 females aged from 37 to 71(with a mean age of 52 years).Nineteen cases of IFP occurred in stomach(18 in an-trum and 1 in body),7 in small intestine(6 in ileum and 1 in jejunum)and 2 in rectum.The solitary non-capsulat-ed polyp was composed of spindle cells, mainly located in the submucosa. Spine cells concentrically arranged around blood vessels with"onion skin"pattern, but those of small intestine were devoid of concentric formations. Twenty-seven cases showed the spindle cells were positive for CD34. Two cases harbored activating mutations in PDGFRA exon 12. Endoscope or surgical excision was adopted as operation method, and showed good therapeutic effect.Conclusions IFP is a rare benign interstitial tumor exhibits two morphologies,which can harbor activating mutation in PDGFRA.CD34 positive can help the diagnosis.
