Bone regeneration around dental implant with bone marrow mesenchymal stem cells sheet and platelet rich plasma
10.3969/j.issn.1001-3733.2018.02.013
- VernacularTitle:骨髓间充质干细胞细胞膜片复合富血小板血浆促进种植体周围骨组织再生的研究
- Author:
Qian LIU
1
;
Wei ZHOU
;
Huan LIU
;
Zhongshan WANG
;
Xuejian LI
;
Yimin ZHAO
Author Information
1. 710032 西安,军事口腔医学国家重点实验室,口腔疾病国家临床医学研究中心,陕西省口腔医学重点实验室,第四军医大学口腔医院修复科
- Keywords:
Dental implant;
Bone regeneration;
Platelet rich plasma(PRP);
Bone marrow mesenchymal stem cells(BMSCs)
- From:
Journal of Practical Stomatology
2018;34(2):206-210
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the bone regeneration capacity of the BMSCs cell sheets combined with PRP used with dental implant. Methods: BMSCs were isolated from young SD rats and induced to form cell sheets(BMSCs); PRP were prepared from the fresh blood of rats; PRP gel with BMSCs fragments(BMSCs + PRP) were injected into the space of dental implant of Ti and β-TCP. BMSCs, PRP and BMSCs + PRP with the implant were respectively transplanted into nude mice(n = 6). 8 weeks after transplantation bone regeneration were examined by Micro CT and hard tissue slicing. Results: The group of BMSCs + PRP showed more new bone formation around implants with blood vessel than the group of BMSCs and PRP. Conclusion: BMSCs sheets with PRP can improve the bone regeneration around dental implants.
