Congenital defects of phagocyte number or function
10.3760/cma.j.issn.2095-428X.2018.04.014
- VernacularTitle:吞噬细胞数量及功能缺陷
- Author:
Jianxin HE
1
Author Information
1. 100045 国家儿童医学中心,首都医科大学附属北京儿童医院呼吸科,国家呼吸系统疾病临床医学研究中心
- Keywords:
Severe congenital neutropenia;
Leukocyte adhesion deficiency;
Chronic granulomatous disease
- From:
Chinese Journal of Applied Clinical Pediatrics
2018;33(4):291-297
- CountryChina
- Language:Chinese
-
Abstract:
Congenital defects of phagocyte number,function or both was categorized to the fifth classification from the international union of immunological societies expert committee for primary immunodeficiency 2015.Severe congenital neutropenia was the most fatal phagocyte number defect.Phagocyte functions included motility,chemotaxis,adhesion,phagocytosis and killing.Leukocyte adhesion deficiency and chronic granulomatous disease were the most common diseases.This article will describe pathogenesis,molecular,clinical,laboratory features and treatment and prognosis,to supporting clues for paediatrician's clinical operations.
