Study on the Relationship between Serum Omentin-1 Level and Degree of Kidney Injuryin Patient with Type 2 Diabetic Nephropathy
10.3969/j.issn.1671-7414.2018.01.029
- VernacularTitle:2型糖尿病患者血清网膜素-1水平与肾损伤程度关系的研究
- Author:
Geng ZHAO
1
Author Information
1. 天津医科大学代谢病医院检验科
- Keywords:
serum Omentin-1;
diabetic nephropathy(DN);
insulin resistance
- From:
Journal of Modern Laboratory Medicine
2018;33(1):115-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between serum Omentin-1 level and degree of kidney in juryin patient with type 2 diabetic nephropathy.Methods 100 diabetic patients with suspected DN were devided into two groups:DM (44 cases) and DN (56 cases) group,and by Mogenson,DN group were devided into DN1 (30 cases) and DN2 (26 cases).In addition 80 healthy subjects were selected as control group.HbA1c,BUN,Scr,β2-MG,HOMA-IR and serum Omentin-1 leves were detected by the standard method.Results There were obvious differences of HbA1c,BUN,Scr,β2-MG,HOMA-IR and Serum Omentin-1 levels among DN,DM and NC (F=6.078～16.231,all P＜0.05).Apart of HbA1c and HOMA-IR,others were no differences between DM group and NC group (t=1.421～2.637,all P＞0.05).There were significant differences of these indicators between DN and NC group (t=8.981～26.785,all P＜0.05).DN group was higher significantly than these in DM group (t=6.371～21.673,all P＜0.05),and HbA1c,BUN,Scr and β2-MG levels had no statistical difference between DN1 and DN2 group (t 0.981～1.389,all P＞0.05).HOMA-IR level in DN2 was higher than that in DN1 group,and serum Omentin 1 declined (t=68.451～76.814,all P＜0.01).There were negative correlation between HOMA IR and serum Omentin-1 leves (r=-0.405,P＜0.05).Conclusion Serum Omentin-1 was related to insulin resistance.Serum Omentin 1 in serum may be a role indicator for impairment of renal function for diagnosis of type 2 diabetic nephropathy.
