Detection and Clinical Significance of Treg and Th1,Th2 Cells in Peripheral Blood of Patients with Immune Thrombocytopenia

VernacularTitle:免疫性血小板减少患者外周血Treg及Th1,Th2细胞检测及其临床意义
Author: Shuo GAO ¹ ; Xue-Jing XU ; Sen WANG ; Li CHENG ; Jun-Hao CHEN ; Jian SUN
Author Information

1. 南京大学医学院附属鼓楼医院检验科
Keywords: immune thrombocytopenia; treg; Th1/Th2
From: Journal of Modern Laboratory Medicine 2018;33(1):112-114
CountryChina
Language:Chinese
Abstract: Objective To detect the level of CD4+CD25+FoxP3+ (Treg) and Th1,Th2 cells in peripheral blood of patients with immune thrombocytopenia and discuss its clinical significance.Methods Flow cytometry was used to detect the percentage of Treg cells and Th1,Th2 cells in peripheral blood of 27 patients with ITP.25 healthy volunteers were detected as control group.Results The percentage of Treg cells in the peripheral blood of patients with ITP was (2.20 ± 0.93)％,which significantly decreased compared with the healthy control group (2.99 ± 0.45) ％ (t =3.820,P＜0.01) respectively,and the levels of Th1,Th2 cells were not statistically different between the two groups (tTh1 =0.655,tTh2 =0.467,all P＞ 0.05).Conclusion Treg cells in patients with ITP were decreased,and its important role in the development of ITP deserves further study.