Study on Combined Determination Plasma NGAL,Cys C and Urinary NAG/Crea for the Diagnosis of Early Diabetic Nephropathy
10.3969/j.issn.1671-7414.2018.01.024
- VernacularTitle:血浆NGAL,Cys C和尿NAG/Crea联合检测对早期糖尿病肾病诊断价值的研究
- Author:
Yang SU
1
;
Qiu-Yan MEI
Author Information
1. 昆明医科大学第一附属医院检验科
- Keywords:
neutrophil gelatinase-associated lipocalin(NGAL);
cystatin C(CysC);
the ratio of urinary microalbumin to creatinine(UALB/Crea);
the ratio of urinary N-acetyl-beta-D-glucosaminidase to creatinine(NAG/Crea);
early diabetic nephropath
- From:
Journal of Modern Laboratory Medicine
2018;33(1):99-101,105
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of plasma neutrophil gelatinase-associated lipocalin (NGAL),cystatin C (Cys C) and the ratio of urinary N-acetyl-beta-D-glucosaminidase to creatinine (NAG/Crea) combined determination in the diagnosis of early diabetic nephropathy.Methods Collected 67 cases of patients with type 2 diabetes hospitalized in the First Affiliated Hospital of Kunming Medical University from December 2016 to February 2017.According to the value of UALB/Crea was divided into two groups:Diabetic urinary microalbumin normal group (UALB/Crea＜30 mg/gCrea) had 35 patients and early diabetic nephropathy group (namely the trace albuminuria group,UALB/Crea 30 ～ 300 mg/gCrea) had 32 patients.Other selected 20 normal volunteers as control group,compared with a medical group to gather all the staff of the clinical data,using automatic biochemical analyzer detected the plasma NGAL,Cys C and urine NAG/Crea,and adopted the receiver-operating characteristic (ROC) curve of the detection index was analyzed.Results ①Plasma NGAL,Cys C and urinary NAG/Crea of diabetic nephropathy patients was significantly higher than those of healthy control group (Z=-5.740 ～-5.386,P＜0.05).②The areaunder receiver operating characteristic (ROC) curve of plasma NGAL,Cys C and urine NAG/Crea were 0.858,0.911 and 0.714.Conclusion Plasma NGAL,Cys C and urinary NAG/Crea combined determination have a higher value for early diagnosis of diabetic nephropathy.
