Analysis of Serum Lp(a) Levels in Patients with Different Genotypes of HCV Infection
10.3969/j.issn.1671-7414.2018.01.012
- VernacularTitle:不同基因型HCV感染患者血清Lp(a)水平检测分析
- Author:
Xiao-Yan ZHOU
1
;
Yue LI
;
Qian HE
;
Jing JI
;
Jia-Li LIU
;
Li XUE
;
Rui-Hua YANG
Author Information
1. 西安交通大学第二附属医院检验科
- Keywords:
lipoprotein (a);
HCV;
genotypes
- From:
Journal of Modern Laboratory Medicine
2018;33(1):49-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether serum Lp(a) level was related to the different genotypes of hepatitis C virus.Methods The serum and corresponding clinical data of 105 patients (male:59,female:46;average age:43.4± 19.8) infected HCV and 30 healthy controls in the Second Affiliated Hospital of Xi'an Jiaotong University from June 2016 to June 2017 were collected.HCV genotypes was detected by PCR-reverse point hybridization,all Lp(a) levels of serum were detected by using automatic biochemical analyzer AU5800 of Beckman.The comparison of the mean of the two samples was applied with t-test,analysis of variance was applied to compare among samples.Results There were 5 genotypes found in 105 patients,including 31 patients with genotype 1b of HCV infection,30 patients with genotype 2a infection,19 patients with genotype 3a infection,12 patients with genotype 3b infection,13 patients with genotype 6a infection.The serum levels of Lp(a) in patients infected with HCV (10.87±6.21 mg/L) were significantly lower than that of healthy controls (21.51± 12.99 mg/L),the difference was statistically significant (t =6.281,P＜0.000 1),meanwhile,the level of each genotype (3 b,6a,2a,3a and 1b was 12.51±6.11,9.75±5.73,12.28±7.63,9.22±4.47 和 10.37±5.75 mg/L,respectively) was lower than that of healthy controls,respectively (t =4.355,3.356,3.965,2.288 and 3.119,all P＜ 0.05),and the difference among genotypes was no statistically significant (F=1.091,P=0.365 4).Conclusion Compared with healthy controls,HCV could reduce the expression of serum Lp(a),but the serum Lp(a) levels were not associated with the genotypes of HCV.
