Analysis of liver function, serum lipid and blood routine in patients with differentiated thyroid cancer before radioactive iodine treatment
10.3969/j.issn.1674-8115.2018.06.008?
- VernacularTitle:分化型甲状腺癌患者碘治疗前肝功能、血脂及血常规水平变化
- Author:
Fei XU
1
;
Ling-Lin TANG
;
Hong YUAN
;
Shao-Li SONG
;
Gang HUANG
Author Information
1. 上海交通大学 医学院附属仁济医院核医学科
- Keywords:
differentiated thyroid cancer;
iodine radioisotopes;
liver dysfunction;
hypothyroidism
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2018;38(6):632-636
- CountryChina
- Language:Chinese
-
Abstract:
Objective·To investigate the effect of temporary hypothyroidism state to liver function, serum lipid and blood routine in patients with differentiated thyroid cancer (DTC) prepared for radioactive iodine treatment. Methods?·?A total of 182 patients with DTC undergoing radical operation of thyroid cancer and radioactive iodine treatment were collected. All these patients were divided into 3 groups by age: 26 in young group (<30 years), 112 in middle-aged group (30-54 years) and 44 in elderly group (?≥?55 years). Indicators of liver function, blood lipids and blood routine were compared before and after operation, among groups as well. Results?·?Patients under hypothyroidism state had significantly elevations in ALT, AST, LDH and serum bile acid, but a notable decrease of serum bilirubin (all P<0.05). Meanwhile they had remarkable elevations in triglyceride, cholesterol, LDL and HDL (all P<0.05). In the young group before thyroid hypothyroidism treatment, the elevation of ALT, AST, LDH and serum bile acid were more significant than those of the middle-aged and elderly patients (all P<0.05). Conclusion?·?The temporary hypothyroidism state of differentiated thyroid cancer patients could elevate liver enzymes as well as dyslipidemia.
