Changes and clinical significance of ischemic modified albumin in patients with polycystic ovary syndrome

VernacularTitle:多囊卵巢综合征患者缺血修饰白蛋白的变化及其临床意义
Author: Huan LI ¹ ; Xiao YANG ; Zhaojun CHEN
Author Information

1. 浙江省杭州师范大学附属医院检验科
Keywords: PCOS; IMA; Oxidative stress; Hyperandrogenemia
From: Chinese Journal of Endocrine Surgery 2017;11(5):417-420
CountryChina
Language:Chinese
Abstract: Objective To investigate the change of ischemia modified albumin (IMA) in polycystic ovary syndrome (PCOS) women,and to examine the relationship between IMA and metabolic disorder.Methods 31 PCOS women (PCOS group) and 28 age-and BMI-matched healthy women (control group) were recruited.Serum IMA levels and related biochemical indexes were compared between the two groups,and the correlation between IMA and each index was analyzed.Results Serum IMA level in PCOS group was significantly higher than that in the control group (P＜0.05).Correlation analysis showed that serum IMA levels were positively correlated with testosterone levels (r=0.57,P=0.03).Conclusion Serum IMA levels in PCOS patients are significantly elevated and closely related to testosterone,suggesting that oxidative stress may be involved in the pathogenesis and development of hyperandrogenemia.