Effects of sufentanil and fentanyl on glucose and insulin in patients of gallbladder surgery using metabonomics technique
- VernacularTitle:舒芬太尼与芬太尼对胆囊切除手术患者血糖和胰岛素代谢组学的影响
- Author:
Guangzhu CHEN
1
;
Qi LIN
;
Yang LIU
;
Hao LI
;
Baowen SUN
Author Information
1. 161006,齐齐哈尔医学院第二附属医院麻醉科
- Keywords:
Sufentanil;
Blood glucose;
Insulin;
Metabonomics
- From:
The Journal of Clinical Anesthesiology
2017;33(12):1185-1188
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of sufentanil and fentanyl anesthesia on blood glucose and insulin levels in patients undergoing laparoscopic cholecystectomy,and explore the mechanism using metabonomics technique.Methods Total 60 patients,37 males and 23 females,ASA physical status Ⅰ or Ⅱ undergoing laparoscopic cholecystectomy were randomly divided into sufentanil and fentanyl groups,and 30 cases in each group.Venous blood was collected before anesthesia and 5 min,40 min and 2 h after anesthesia,which was used to detect blood glucose,insulin levels and metabonomics analysis.Results Blood glucose were significantly lower in sufentanil group than in fentanyl group at 5 min after intubation,40 min in surgery,and postoperative 2 h (P＜0.05).After 2 h,insulin in sufentanil group was significantly lower than that in fentanyl group (P＜0.05).Metabolic analysis showed that in the positive ion mode,using orthogonal partial least squares discriminant analysis,the patients in the two groups were classified according to the serum metabolites at postoperative 2 h,which showed that the serum metabolites in patients of different groups were significantly different,and 5 biomarkers closely related to blood glucose and insulin were found.Conclusion Sufentanil showed slighter effects on blood glucose and insulin in patients,and more suitable for cholecystectomy patients.The mechanism may be related with the glucose and insulin metabolism.
