The value of genetic polymorphisms of mycophenolate mofetil in individualized therapy
10.3969/j.issn.1000-3606.2018.05.016
- VernacularTitle:基因多态性对儿童霉酚酸酯个体化治疗的意义
- Author:
Zhiqing ZHANG
1
Author Information
1. 复旦大学附属儿科医院肾内科 上海市肾脏发育和儿童肾脏病研究中心
- Keywords:
mycophenolic acid;
genetic polymorphisms;
individualized therapy;
child
- From:
Journal of Clinical Pediatrics
2018;36(5):384-388
- CountryChina
- Language:Chinese
-
Abstract:
Mycophenolate mofetil (MMF) is a cornerstone immunosuppressant in clinical therapy, such as organ transplantation. Because of the huge interindividual difference in genetic polymorphisms and some other, fixed-dose MMF-treated strategy can neither attain the targeted effective and safe MPA blood concentration nor satisfy the needs of individualized therapy,especially in children.The article reviews the value of genetic polymorphism of UGT,IMPDH,ABCC2,SLCO in MMF therapy in children to highlight its role in the precision treatment.
