Progress on minimal residual diseases in childhood solid tumor
10.3969/j.issn.1000-3606.2018.02.015
- VernacularTitle:儿童常见实体瘤微小残留病检测研究进展
- Author:
Jie ZHAO
1
Author Information
1. 上海交通大学医学院附属上海儿童医学中心血液/肿瘤科 国家卫计委儿童血液肿瘤重点实验室 上海 200127
- Keywords:
minimal residual diseases;
child;
solid tumor
- From:
Journal of Clinical Pediatrics
2018;36(2):149-154
- CountryChina
- Language:Chinese
-
Abstract:
Minimal residual disease (MRD) is a major cause of solid tumor relapse, which refers to the small number of malignant cells remained after therapy that cannot be detected by conventional imaging examination and morphological examination. Whereas flow cytometry and polymerase chain reaction based methods constitute the two most commonly used techniques for MRD detection. Next generation sequencing will certainly be widely employed in individual MRD detection by testing on specific genetic change in the future. This article is to review the progress on MRD detection methods in childhood solid tumor.
