Research Progress of the Relationship between Arginase Inhibitors and Diabetic Vascular Endothelial Function

VernacularTitle:精氨酸酶抑制剂与糖尿病血管内皮功能关系的研究进展
Author: Li LI ¹ ; Jia WANG ; Juan DU ; Ting-Yu KE
Author Information

1. 昆明医科大学第二附属医院内分泌科
Keywords: NO; NOS; Arginase inhibitors; Vascular endothelial function
From: Journal of Kunming Medical University 2018;39(2):120-123
CountryChina
Language:Chinese
Abstract: Endothelial dysfunction is a major risk factor for vascular complication. Nitric oxide (NO),the most important product of endothelial cells,lays a key role in regulating vasomotor as an endogenous vasodilatation factor. NO is produced by endothelial NO synthase (eNOS) on its substrate L-arginine. Arginase,which metabolizes L-arginine to urea and ornithine,competes directly with eNOS for L-arginine leading to the decrease of NO production. This paper reviews the basic role of arginase, the development of arginase inhibitors and its effects on diabetic vascular complications.