The Determination of Cut-off Value of TSH during Screening of Congenital Hypothyroidism in 6 Prefecture/City of Yunnan Province
10.3969/j.issn.1003-4706.2018.01.016
- VernacularTitle:云南省6州/市先天性甲状腺功能减低症筛查中TSH切值的确立
- Author:
Qiong WANG
1
;
Zhi-Ye QI
;
Xiao-Long ZHAO
;
Qing-Hua ZHONG
;
Cai-Ying ZHANG
;
Kun LIANG
;
Jiang DUAN
Author Information
1. 昆明医科大学第一附属医院新生儿遗传代谢病筛查中心
- Keywords:
Neonatal screening;
Congenital hypothyroidism(CH);
Thyroid-stimulating hormone(TSH);
Cut-off value
- From:
Journal of Kunming Medical University
2018;39(1):69-72
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the positive cut-off value in neonatal screening for congenital hypothyroidism(CH)in the center of Neonatal Screening , so as to improve screening efficiency and reduce false positive rate. Methods Heel blood samples were taken from the newborns born after72 hours,dropped in special S&S903 filter paper and delivered to the neonatal screening center within the prescribed period of time.DELFIA was applied to detect the concentration of thyroid-stimulating hormone(TSH).Result Totally 529918 blood sample were screened from the 2012 to the 2016.Among them 529645 newborns were normal, 203 neonates were diagnosed with CH, 70 with high TSH hyperlipidemia, the total detection rate was 1:1941, and the incidence of CH was 1:2610. According to the results, the cut-off value of the screening of CH in the center of Neonatal Screening was 9.0 mIU/L, the sensitivity was 100％and specifility was 98.38％, misdiagnosis rate was 0％. Conclusion The cut-off value of CH was 9.0 mIU/L in the center of Neonatal Screening ,which is suitable for the people in 6 Prefecture/City of Yunnan Province , and also provides the basis for neonatal scree of CH in the future.
