Effects of the Aerobic Exercise on the AGE-RAGE Axis and NF-κB Pathway in T2DM Rats
10.3969/j.issn.1003-4706.2018.01.004
- VernacularTitle:有氧运动对2型糖尿病大鼠AGE-RAGE轴及NF-κB通路的影响
- Author:
Zhi-Xiang SHEN
1
;
Li-Xun ZHU
;
Wei-Hong XU
Author Information
1. 上海市同仁医院康复科;上海交通大学医学院附属同仁医院康复科
- Keywords:
Type 2 diabetes mellitus;
Aerobic exercise;
Advanced glycation end products;
Receptor of AGE;
Nuclear factor-kappa B
- From:
Journal of Kunming Medical University
2018;39(1):16-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study was to evaluate the effects of aerobic exercise on AGE-RAGE axis and nuclear factor kappa B pathway in type 2 diabete rats and to discuss the rehabilitation function of aerobic exercise in type 2 diabetes mellitus (T2DM) . Methods After the 8-week-old male Wistar rats were fed with a high sugar and high fat for 4 weeks, type 2 diabetes rats were induced by streptozotocin way. 30 type 2 diabetes rats were allocated at random into 3 groups:type 2 diabetes mellitus (T2DM), low- and moderate- intensity exercise groups (T2DML, T2DMM) . Exercise group performed exercise protocol respectively. The AGEs, RAGE and NF-κB levels of the blood,muscle and heart were detected by ELISA method respectively. Results Compared with T2DM group, the NF-κB level of the blood, muscle and heart were decreased in T2DML group significantly (P<0.05);the AGEs, RAGE and NF-κB level of the blood, muscle and heart were decreased in T2DMM group significantly ( <0.05) . Compared with T2DML group, the NF-κB level of the blood, muscle and heart were decreased in T2DMM group significantly ( <0.05) . Conclusion Moderate intensity aerobic exercise inhibits AGE-RAGE axis and NF-κB pathway, which may decrease oxidative stress and inflammation, and so reduce tissue injure for the prevention and treatment of complications of the T2DM.
