Progress of research on NLRP3 inflammasome in kidney ischemia-reperfusion injury

VernacularTitle:NLRP3炎症小体在肾缺血再灌注损伤中的作用
Author: Kang WU ¹ ; Ming CAI
Author Information

1. 100091,北京解放军309医院器官移植研究所泌尿外科、器官移植与免疫调节北京市重点实验室
Keywords: kidney transplantation; ischemia-reperfusion injury; NLRP3 inflammasome
From: Medical Journal of Chinese People's Liberation Army 2017;42(12):1102-1105
CountryChina
Language:Chinese
Abstract: Ischemia-reperfusion injury is an inflammatory cascade involving a variety of factors.It is closely related to the delayed graft function and acute rejection after renal transplantation.At present,the mechanism of ischemia-reperfusion injury is not clear.Recent studies have shown that NLRP3 inflammasome,as a key molecule of inflammatory cascade,plays an important role in the development and progression of renal ischemia-reperfusion injury.Therefore,it is expected to become a new therapeutic target for renal ischemia-reperfusion injury.This article reviews the role of NLRP3 inflammasome in renal ischemia-reperfusion injury.