Relativity of gene polymorphism of aldehyde dehydrogenase 2 to premature coronary heart disease
10.11855/j.issn.0577-7402.2017.12.11
- VernacularTitle:乙醛脱氢酶2基因多态性与早发冠心病的相关性研究
- Author:
Ling JIANG
1
;
Yu-Qian LI
;
Jian-Wei TIAN
;
Pei LIU
;
Lin-Hai WANG
;
Chao-Zhong LIU
Author Information
1. 100142北京,安徽医科大学空军临床学院心脏中心内科
- Keywords:
premature coronary heart disease;
aldehyde dehydrogenase 2;
polymorphism,single nucleotide;
gene
- From:
Medical Journal of Chinese People's Liberation Army
2017;42(12):1083-1087
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between aldehyde dehydrogenase 2 (ALDH2) gene polymorphism and premature coronary heart disease (CHD) in Chinese Han population.Methods A total of 505 patients were enrolled in the present study.Of them,375 were definitely diagnosed as CHD and another 130 were excluded from CHD by coronary angiography.Coronary heart disease patients were divided into premature coronary heart disease (male ＜55 years,female ＜65 years) group (n=150) and late onset coronary heart disease (male ≥ 55 years,female ≥ 65 years) group (n=225);According to whether after drinking flushing,the enrolled 505 patients were divided into alcohol flushing syndrome(AFS) group (n=135) and no AFS group (n=370);According to whether used to drinking,they were divided into accustomed to drinking group (n=189) and no drinking custom group (n=316).The ALDH2 gene polymorphism was analyzed by sanger sequencing.Results There was no significant difference in the distribution ofALDH2 genotype between the patients with premature CHD and late-onset CHD,also between CHD and non-CHD (P＞0.05).The logistic regression analysis showed that ALDH2 gene was not a predisposing factor of PCHD and CHD after adjusting for gender,age,smoking,drinking,body mass index (BMI),hypertension,diabetes,hyperlipidemia and family history of CHD (P=0.729,OR=1.098,95％CI 0.648-1.859;P=0.581,OR=1.156,95％CI 0.692-1.930).The incidence of ALDH2 mutant (GA+AA) was significantly higher in AFS group than in no AFS group (67.4％ vs.10.5％,P＜0.01).The gene mutation frequency was markedly higher in no drinking custom group than in accustomed to drinking group (29.7％ vs.19.1％,P＜0.01).Conclusions No obvious correlation exists between ALDH2 gene polymorphism and the incidence of premature CHD or the onset of CHD in Chinese Han population.There is a certain relationship between ALDH2 mutant gene and AFS.
