The clinical study on the effect of Tongyang-Kuanxiong guanule (TKG) for the stable angina pectoris patients with the type of Qi and phlegm stasis
10.3760/cma.j.issn.1673-4246.2018.02.003
- VernacularTitle:通阳宽胸颗粒配合西医常规疗法治疗气滞痰瘀证稳定型心绞痛临床研究
- Author:
Haolong ZHENG
1
;
Lili JIN
Author Information
1. 510405,广州中医药大学
- Keywords:
Angina;
stable;
Syndrome differentiation classification;
Tongyang-Kuanxiong guanule;
Treadmill exercise testing
- From:
International Journal of Traditional Chinese Medicine
2018;40(2):103-106
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Tongyang-Kuanxiong guanule combined with conventional western medicine for the stable angina pectoris (SAP) with qi and phlegm and blood stasis syndrome. Methods Eighty-six SAP patients who met the inclusion criteria were randomly divided into two groups according to the digital table method, with 43 cases in each group. The control group was treated with routine Western medical therapy. The observation group was given Tongyang-Kuanxiong guanule on the basis of the control group. Both groups were treated for 28 days. The TCM syndromes and angina pectoris scores were evaluated before and after treatment. The treadmill exercise test was used to observe the duration of exercise, the metabolic equivalent, the maximum value of ST segment depression, the heart rate at maximum load, the duration of ST segment depression. And the adverse reactions were recorded. Results The total effective rate was 88.4％ (38/43) in the observation group and 67.4％ (29/43) in the control group. The difference between the two groups was statistically significant (χ2=5.549, P=0.018). After treatment, the duration of exercise (9.5 ± 1.2 min vs. 8.6 ± 1.2 min, t=3.371), metabolic equivalent (10.8 ± 2.5 METs vs. 9.2 ± 2.4 METs, t=3.084) in the observation group were significantly higher than those in the control group (P<0.01 or P<0.05). The largest degree of ST segment changes (1.2 ± 0.6 mV vs. 1.9 ± 0.6 mV, t=5.484), and the duration of ST segment descent (125.0 ± 94.5 s vs. 162.4 ± 96.9 s, t=1.795) in the observation group were significantly lower than those in the control group (P<0.01 or P<0.05). Thefrequency of angina attacks (9.7 ± 1.6 times per week vs. 17.3 ± 2.1 times per week, t=18.778), duration of attacks (3.2 ± 1.4 min vs. 6.4 ± 1.5 min, t=10.146) consumption of nitroglycerin (1.3 ± 0.8 mg vs. 2.5 ± 0.8 mg, t=7.624) and Symptom score (8.3 ± 2.8 vs. 12.5 ± 3.1, t=6.593) in the observation group were significantly lower than the control group (P<0.01). Conclusions The Tongyang-Kuanxiong guanule can significantly improve the exercise tolerance of SAP patients with qi and phlegm and blood stasis, reduce myocardial oxygen consumption, improve angina pectoris and reduce the number of angina attacks.
