Circular RNA and its application in gynecological carcinoma

VernacularTitle:环状RNA及其在妇科肿瘤中的应用
Author: Panchan ZHENG ¹ ; Xiao SUN ; Lihua WANG
Author Information

1. 200030,上海交通大学医学院附属国际和平妇幼保健院妇科肿瘤科
Keywords: MicroRNAs; Genital neoplasms,female; Gene expression regulation; Circular RNA
From: Journal of International Oncology 2018;45(5):308-311
CountryChina
Language:Chinese
Abstract: Circular RNAs (circRNAs) are a class of RNA which forms covalently closed loops.They act as microRNA (miRNA) sponge in the circRNA-miRNA-mRNA regulatory axis,regulating gene transcription and protein translation.CircRNAs are differently expressed in gynecological carcinoma.They can affect the proliferation,invasion and migration of gynecological tumor cells,playing a role in inhibiting or promoting cancer.CircRNAs are featured with characteristics of stabilities,abundance,specificity and conservative,making it a potential target for the prediction,diagnosis and treatment of gynecologic tumors.