Detection and clinical application of minimal residual disease in multiple myeloma

VernacularTitle:多发性骨髓瘤微小残留病的检测方法及临床应用
Author: Xiaolan LIU ¹ ; Tao GUAN ; Liping SU
Author Information

1. 山西省肿瘤医院(山西省第三人民医院)血液科
Keywords: Multiple myeloma; Neoplasm,residual
From: Journal of International Oncology 2018;45(1):56-58
CountryChina
Language:Chinese
Abstract: Minimal residual disease (MRD) is a very important prognostic factor in multiple myeloma (MM).The major types of MRD tests include cell-based test (multi-parameter flow cytometry) and molecular tests (including PCR and gene sequencing),and the various techniques have inherent advantages and limitations.In clinical application,MRD negative can significantly prolong progression-free survival and overall survival of patients who receive hematopoietic stem cell transplantation and conventional che-motherapy.Moreover,the MRD status is of great significance to the selection of treatment options.