Progress in research on the interaction between pancreatic stellate cells and tumor cells
10.3760/cma.j.issn.1673-4203.2018.09.016
- VernacularTitle:胰腺星状细胞与肿瘤细胞相互作用的研究进展
- Author:
Hongpeng ZHANG
1
;
Dong TANG
;
Daorong WANG
Author Information
1. 225001,扬州大学附属苏北人民医院普通外科扬州大学—扬州市普通外科研究所
- Keywords:
Tumor microenvironment;
Pancreatic neoplasms;
Neoplasm metastasis;
Pancreatic stellate cells;
Infiltration
- From:
International Journal of Surgery
2018;45(9):641-644
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer is one of the most common digestive tract malignant tumors with poor prognosis and low rate of the surgical resection,which has been a major difficulty in clinical surgeons.In recent years,the study founds that the interaction relations activated pancreatic stellate cell in the pancreas tumor microenvironment and cancer cells plays a very important role in the development of tumor.The cancer cells promote the activation of pancreatic stellate cells,secretion,and metastasis,at the same time,the pancreatic stellate cells can promote the proliferation,invasion,metastasis of cancer cells,and has a dual function of promotion and suppression the formation of new blood vessels around the tumor and immune suppression.Therefore,deeply study of the PSC will help us figure out the regulation of tumor development and initiate a new way for treatment of pancreas tumor at the cell and molecular level.
