Role and mechanism of heme oxygenase-1 in cerebral ischemia-reperfusion injury
10.3760/cma.j.issn.1673-4165.2018.06.013
- VernacularTitle:血红素加氧酶-1在脑缺血再灌注损伤中的作用和机制
- Author:
Wenjuan QIU
1
;
Jianhong WANG
;
Fuqiang GUO
Author Information
1. 646000 泸州,西南医科大学临床医学院;610072 成都,四川省人民医院(四川省医学科学院) 神经内科
- Keywords:
Brain Ischemia;
Reperfusion Injury;
Heme Oxygenase-1;
Inflammation;
Oxidative Stress;
Apoptosis;
Neovascularization,Physiologic;
Signal Transduction;
Neuroprotective Agents
- From:
International Journal of Cerebrovascular Diseases
2018;26(6):464-467
- CountryChina
- Language:Chinese
-
Abstract:
Heme oxygenase (HO) -1 is the most bioactive HO type. It reduces tissue damage by exerting antioxidant, anti-inflammatory, and cytoprotective effects during ischemia-reperfusion injury. It is considered to be a new direction for the treatment of ischemia-reperfusion injury. This article reviews the role of HO-1 in ischemia-reperfusion injury and its possible mechanisms.
