Microtubule abnormalities in the pathogenesis of cardiomyopathy
10.3760/cma.j.issn.1673-4408.2017.12.004
- VernacularTitle:微管异常在心肌病发生中的作用机制
- Author:
Yuanlin ZHOU
1
Author Information
1. 400014,重庆医科大学附属儿童医院心内科
- Keywords:
Microtubule;
Microtubule-associated protein;
Cardiomyopathy;
Mechanism
- From:
International Journal of Pediatrics
2017;44(12):826-830
- CountryChina
- Language:Chinese
-
Abstract:
Microtubules are dynamic hollow tubes mainly found in the cytoplasm of eukaryotic cells.Tubulin heterodimers,the basic structures of microtubules,are assembled by α/β-tubulin subunits from head-to-tail and spirally.Microtubules are cytoskeletal structures that play an essential role in maintaining cell physiological function,including cell shape maintaining,intracellular transport,formation of mitotic spindle,modulating cell polarity,formation of flagellum and so forth.Moreover,the stability of microtubule structure is modulated by tubulin modifications and microtubule-associated proteins,and the dynamic modulation plays a fundamental role in myocardial hypertrophy,Duchenne muscular dystrophy (DMD)and diabetic cardiomyopathy.However,the molecular mechanism of microtubule in the pathogenesis of cardiomyopathy remains unclear.Here,the latest research and the molecular mechanism are reviewed.
