Clinical features of de novo primary AML patients with multiple mutated genes
10.3969/j.issn.1671-8348.2018.13.015
- VernacularTitle:伴有多种突变基因的初治原发AML的临床特征分析
- Author:
Yang JIAO
1
Author Information
1. 郑州大学附属肿瘤医院检验科
- Keywords:
mutation;
genes;
leukemia,myeloid,acute;
disease attributes
- From:
Chongqing Medicine
2018;47(13):1751-1755
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical features of de novo primary acute myeloid leukemia (AML) patients with multiple mutated genes.Methods Clinical data of de novo primary AML patients in hospital from January 2015 to December 2016 were retrospectively reviewed,including 76 cases of male patients and 68 female patients,the median age was 41.50 years old with inter-quartile range from 25.25 to 53.75 years old.Based on the theory of "two kinds of mutation theory",all the patients were divided into the group with gene mutation number (GMN)＜2 (105 cases) and the group with GMN≥2 (39 cases),and analyzed the types of clinical data.Results Comparing the age and peripheral serous white blood cell (WBC) between the two groups,there were statistically significant differences (P＜0.05);the group with GMN≥2 had a higher proportion of mutations in FLT3-ITD,NRAS,WT1,CEBPA,NPM1,RUNX1,EP300,DNMT3A,IDH1,IDH2 and TET2 (P＜0.05).Conclusion The de novo primary AML patients,who have multiple mutated genes,have higher proportion in elder people and higher peripheral serous WBC,and the mutated genes with different functions often coexist.
