Arterial Ageing.
- Author:
Seung Jun LEE
1
;
Sung Ha PARK
Author Information
- Publication Type:Review
- Keywords: Aging; Arterial stiffness; Pulse wave analysis; Atherosclerosis
- MeSH: Aging; Arteries; Atherosclerosis; Hypertension; Inflammation; Oxidative Stress; Progeria; Pulse Wave Analysis; Renin-Angiotensin System; Sclerosis; Vascular Stiffness
- From:Korean Circulation Journal 2013;43(2):73-79
- CountryRepublic of Korea
- Language:English
- Abstract: Arterial ageing is characterized by age associated degeneration and sclerosis of the media layer of the large arteries. However, besides ageing, clinical conditions, which enhance oxidative stress and inflammation act to accelerate the degree of arterial ageing. In this review, we summarized the pathophysiology and contributing factors that accelerate arterial ageing. Among them, we focused on hypertension, the renin-angiotensin-aldosterone system and vascular inflammation which are modifiable causes of the arterial ageing process. Also, novel treatment targets derived from the disease models such as the Hutchinson Gilford Progeria Syndrome were reviewed.
