Impacts of multicomponent environment on intrinsic dissolution rate of berberine in biopharmaceutics classification system of Chinese materia medica.
- Author:
Xiu-Wen YIN
1
;
Zi-Yu WANG
1
;
Meng PAN
1
;
Xin ZHANG
1
;
Jing WANG
1
;
Yan-Ping LI
1
;
Ling DONG
1
Author Information
- Publication Type:Journal Article
- Keywords: berberine; biopharmaceutics classification system of Chinese materia medica; intrinsic dissolution rate
- From: China Journal of Chinese Materia Medica 2018;43(11):2269-2273
- CountryChina
- Language:Chinese
- Abstract: To illustrate the intrinsic dissolution rate(IDR) involved in biopharmaceutics classification system of Chinese materia medica(CMMBCS), investigate the effect of artificial multicomponent environment on IDR of berberine, by using a non-disintegrating disk, and summarize related rules by using the obtained data. Progressive levels design was used to investigate the effects of single component environment (puerarin, baicalin, and glycyrrhizic acid); double-component environment(puerarin+baicalin, puerarin+ glycyrrhizic acid, baicalin+glycyrrhizic acid); and triple-component environment(puerarin+baicalin+glycyrrhizic acid) on IDR of berberine, laying a foundation for further researches on the absorption mechanism of multiple components.
