Effects of Synthetic Long-Chain Polyphosphate on Blood Coagulation and Platelet Aggregation.

Feng YU; Xiao-Yang YANG; Meng-Jie WAN; Mei-Qing LEI; Ling-Feng SUN; Xu HAN; Wen-Jin LI; Fang-Ping CHEN

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Effects of Synthetic Long-Chain Polyphosphate on Blood Coagulation and Platelet Aggregation.

Author: Feng YU ¹ ; Xiao-Yang YANG ^{2
,

3} ; Meng-Jie WAN ¹ ; Mei-Qing LEI ¹ ; Ling-Feng SUN ¹ ; Xu HAN ¹ ; Wen-Jin LI ⁴ ; Fang-Ping CHEN ⁵
Author Information

1. Department of Hematology, Affiliated Haikou Hospital, Xiangya School of Medicine,Central South University & Haikou Peaple's Hospital, Haikou 570208, Hainan Province, China.
2. Department of Hematology, Affiliated Haikou Hospital, Xiangya School of Medicine,Central South University & Haikou Peaple's Hospital, Haikou 570208, Hainan Province, China. E-mail:y108108@
3. com.
4. Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
5. Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.E-mail: xychenfp@qq.com.
Publication Type:Journal Article
From: Journal of Experimental Hematology 2018;26(5):1477-1483
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the effects of synthetic long-chain polyphosphate on blood coagulation and platelet aggregation.
METHODSThe effect of artificial synthetic long chain poly phosphate on blood coagulation and platelet aggregation was detected by coagulation tests, coagulation factor activity detection and platelet aggregation test, and its mechanism was explored by ELISA, flow cytometry and high content imaging system.
RESULTSThe long chain polyphosphates prolonged activated partial thromboplastin time, decreased coagulation factor FⅧ, FⅨ, FⅪ and FⅫ activity, blocked ADP-induced platelet aggregation, and decreased the concentration of calcium and TXA2 in platelet.
CONCLUSIONThe synthetic long-chain polyphosphate can inhibit endogenous coagulation and inhibit platelet aggregation, which may be related with the inhibition of intracellular calcium and TXA2.