Local injection of exogenous nerve growth factor improves early bone maturation of implants.
- VernacularTitle:局部注射外源性神经生长因子促进小鼠钛种植体周骨胶原早期成熟的研究
- Author:
Yang YAO
1
;
Yu DU
1
;
Xia GU
1
;
Meng-Kai GUANG
1
;
Bo HUANG
1
;
Ping GONG
1
Author Information
- Publication Type:Journal Article
- Keywords: nerve growth factor; osseointegration; titanium implant
- From: West China Journal of Stomatology 2018;36(2):128-132
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of nerve growth factor (NGF) in the osteogenic action of implants and the maturation and reconstruction changes in bone tissues in the early stage of osseointegration.
METHODSThe mouse implant model was established by placing titanium in the femoral head of the mouse and locally injecting NGF in the implant zone. On 1, 2 and 4 weeks after operation, stain samples were collected from animals using hematoxylin-eosin (HE) staining and Masson staining. The effect of NGF on the bone maturation was compared at different time points of early stage osseointegration.
RESULTSThe results of HE and Masson staining indicated that the local injection of external NGF can up-regulate bone mass, amount of bone trabecula, and bone maturity in the mouse model. The mature bone rate in treatment group of 1 week and 4 weeks after operation were significantly higher than those in the control group (P<0.05).
CONCLUSIONSNGF can shorten the period of bone maturation.
