Review of high-resolution peripheral quantitative computed tomography for the assessment of bone microstructure and strength.
10.7507/1001-5515.201707068
- Author:
Jianxiong MA
1
;
Jie ZHAO
2
;
Weiwei HE
2
;
Mingjie KUANG
2
;
Hengting CHEN
2
;
Lukai ZHANG
2
;
Lei SUN
2
;
Yuhong CUI
3
;
Xinlong MA
2
;
Ying WANG
2
Author Information
1. School of Mechanical Engineering, Tianjin University, Tianjin 300072, P.R.China;Orthopaedics Institute, Tianjin Hospital, Tianjin 300211, P.R.China;Orthopaedics Institute, Tianjin University Tianjin Hospital, Tianjin 300211, P.R.China.
2. Orthopaedics Institute, Tianjin Hospital, Tianjin 300211, P.R.China;Orthopaedics Institute, Tianjin University Tianjin Hospital, Tianjin 300211, P.R.China.
3. School of Mechanical Engineering, Tianjin University, Tianjin 300072, P.R.China.
- Publication Type:Journal Article
- Keywords:
bone density;
bone microstructure;
bone strength;
high-resolution peripheral quantitative computed tomography
- From:
Journal of Biomedical Engineering
2018;35(3):468-474
- CountryChina
- Language:Chinese
-
Abstract:
Trabecular microstructure is an important factor in determining bone strength and physiological function. Normal X-ray and computed tomography (CT) cannot accurately reflect the microstructure of trabecular bone. High-resolution peripheral quantitative computed tomography (HR-pQCT) is a new imaging technique in recent years. It can qualitatively and quantitatively measure the three-dimensional microstructure and volume bone mineral density of trabecular bone . It has high precision and relative low dose of radiation. This new imaging tool is helpful for us to understand the trabecular microstructure more deeply. The finite element analysis of HR-pQCT data can be used to predict the bone strength accurately. We can assess the risk of osteoporosis and fracture with three-dimensional reconstructed images and trabecular microstructure parameters. In this review, we summarize the technical flow, data parameters and clinical application of HR-pQCT in order to provide some reference for the popularization and extensive application of HR-pQCT.
