Advances in study of plant type Ⅲ polyketide synthases.
10.19540/j.cnki.cjcmm.20180514.003
- Author:
Bin-Bin WANG
1
;
Jian-He WEI
2
;
Zhen-Qiao SONG
1
;
Zhi-Hui GAO
2
Author Information
1. College of Agronomy, Shandong Agricultural University, Tai&an 271018, China.
2. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education & National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
- Publication Type:Journal Article
- Keywords:
enzyme engineering;
expression regulation;
molecular evolution;
type Ⅲ polyketide synthase
- From:
China Journal of Chinese Materia Medica
2018;43(13):2639-2647
- CountryChina
- Language:Chinese
-
Abstract:
Polyketides are a large class of natural products with notable structural diversity and different biological activities. They have essential pharmacological value for human health. In plants, the enzymes responsible for the formation of phenolic metabolites backbone structures are collectively known as type Ⅲ polyketide synthases (PKSs), which are the key enzymes for the polyketides biosynthesis. The PKSs catalyze a series of condensation reactions of two-carbon acetate units with an acyl starter. A brief overview of this group of enzymes, including their reaction mechanisms, function modification, expression regulation, molecular evolution, and recent interesting findings are presented here.
