A comparative study on the changes of serum fibrosis indicators after TACE with use of low-dose versus con- ventional-dose of anticancer drugs in hepatocellular carcinoma
- VernacularTitle:小剂量与常规剂量化疗药物经导管栓塞化疗对肝癌患者血清肝纤维化指标的影响
- Author:
Wei LU
;
Yanhao LI
;
Xiaofeng HE
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Carcinoma, hepatocellular;
Chemoembolization, therapeutic;
Anticancer drug;
Liver fibrosis
- From:
Journal of Interventional Radiology
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of serum fibrosis indicators after transcatheter arterial chemoembolization (TACE) with the use of low dose vs conventional dose of anticancer drugs in hepatocellular carcinoma (HCC). Methods Forty patients with HCC were divided into two groups to receive superselective TACE. Patients in group A( n =20) received low dose anticancer drug(s):2-4 mg mitomycin C (MMC) with the tumor mass less than 5 cm in size; while MMC 4-6 mg and epirubicin (EPI) 10 mg were given with tumon size of 5-8 cm in diameter, and MMC 6-8 mg, EPI 10 mg, CBP 100 mg with tumors larger than 8 cm. Patients in group B ( n =20) were given conventional dose of anticancer drugs (MMC 10 mg, EPI 40 mg and CBP 300 mg). Lipiodol anticancer drugs emulsion was injected into the feeding arteries of tumors and followed by gelatin sponge or PVA particles embolization participation. Four serum fibrosis indicators, including hyaluronate acid (HA), human procollagen type Ⅲ (hPC Ⅲ), laminin (LN), collagen type Ⅳ(Ⅳ C) were assessed before and 7 days after TACE. Results There was no significant difference between the two groups concerning the four indicators before TACE, but the concentrations of the four serum indicators were increased siginificantly in group B ( P 0.05). Conclusions The formation of liver fibrosis after TACE in HCC is related to the dosage of anticancer drugs employed for chemoembolization. Therefore, low dose anticancer drugs should be advocated.
